ABBACO SZN - ISS

ABBACO SZN - Conisma 

ABBACO SZN - Università degli Studi di Napoli Federico II

ABBACO SZN - DICEA

ABBACO SZN - ENEA

ABBACO SZN - IAMC

ABBACO SZN - INGV

ABBACO SZN - ISAC

ABBACO SZN - Università degli Studi di Napoli "Parthenope"

ABBACO SZN - Università degli Studi della Campania "Luigi Vanvitelli"

ABBACO SZN - Università Politecnica delle Marche

Responsible: Adrianna Ianora

Activities

The Biotechnology Laboratory is a multidisciplinary lab that uses and develops different approaches dedicated to the study of marine drug discovery. Research activities include sampling, isolation and maintenance of marine species of biotechnological interest (especially microalgae), preparation of chemical extracts, testing the potential bioactivity at the gene and protein levels of extracts on human cells and model marine organisms.

Experimental Systems

• Molecular and chemical facilities applied to marine biotechnology.
• Human cell culture chambers (biological hood type 1, incubator for human cells, microscopes).
• Rooms for microalgal growth.
• Room with 2 Bioreactors.

Analysis

• Isolation and maintenance of microalgae for potential biotechnological applications.
• Cultivation of microalgae at the small (flasks), medium (10L carboys) and large scale (photobioreactors 100 L).
• Genotyping of new species by DNA sequencing.
• Bioassays testing biological activity of extracts, fractions and pure compounds on marine model species and human cell lines.
• Antiproliferative and clonogenic bioassays against aggressive tumor cell lines.
• Antioxidant and anti-inflammatory bioassays on normal cell lines.
• Cellular senescence (anti-aging)bioassays.
• Chronic human diseases (diabetes, Alzheimer's, Crohn's disease) bioassays.
• Molecular studies at the gene and protein levels to identify specific pathways activated by bioactive compounds on human cells (retroviral transfection, PCR array, immunoblot, ELISA).
• Transcriptome analysis of microalgal species.

Equipment

• Basic instrumentation for molecular biology and protein analysis (PCR, centrifuges, electrophoresis apparatus, transilluminator, thermostatic baths, spectrophotometer, pH meter, transblot).
• Biological Type 2 hood for micralgal cultures.
• Chemical hood.
• Microscopes.
• 2 photobioreactors (100 L).

For more information and to book a visit: https://fondazionedohrn.it/home/dadom/

The Darwin-Dohrn Museum

Dedicated to the two giants of science and evolutionary biology, Charles Darwin and Anton Dohrn, the Darwin-Dohrn Museum - DaDoM – promotes the knowledge of the evolution of marine biodiversity.
Inside the DaDoM, visitors will voyage through the oceans through time in the footsteps of Darwin and Dohrn and many other scientists, discovering how organisms became adapted to all marine environments. In this journey through time and research, the public will understand the importance of the oceans in determining the conditions on the planet, will encounter the primordial forms of life that appeared in the oceans over 3 billion years ago, will discover evolutionary theories, and will encounter a series of fossils that show the evolution of forms and functions over the geological eras (walk through time).
Works of art, sculptures and historical biological samples will show how marine organisms move, feed, and reproduce, and the mechanisms that led to current life forms, in a gallery of biodiversity, from the simplest to the most complex organisms, to arrive at the multipurpose room of the DaDoM, housing a large skeleton of a sperm whale (beached along the Campania coasts and recovered by researchers), enriched by models of organisms that feed on the carcasses of these majestic giants of the sea when they arrive in the depths of the sea. The multipurpose room is dominated by a six-meter high wall that houses ten thousand preparations of animals from the Gulf of Naples, set up by the genius of Salvatore Lo Bianco and by those who followed his footsteps in the art of conservation.
The multipurpose room is designed to host thematic exhibits to explore topics of great scientific and popular interest, but also for scientific conferences and seminars, and is available to the cultural world for other initiatives of public interest, such as shows, concerts, exhibitions and film broadcasts. The museum itinerary also includes a journey through the studies and ancient maps of the Gulf of Naples, the discoveries of the over 20 Nobel laureates who conducted their studies in the SZN, up to the current research updated and exhibited month by month.
The Museum includes a large educational laboratory for students of all types and levels designed to carry out practical observation and study activities aimed at discovering the secrets of marine life. The upper floor of the building includes the staff offices, laboratories and organizations hosted by the Center. The Anton Dohrn Zoological Station has returned to the citizens of Naples, Campania and the whole country an asset of the city in its full fruition. This objective will also be extended to the outside of the building, making the garden of the Museum a place of knowledge in the open air. In fact, the garden hosts two scientific submersibles made available by the MareAmico Cultural Association and which have also been used for the exploration of the deep sea environments of the Mediterranean.
Depending on specific needs, the rear lawn or the roof terrace will finally host an open-air summer cinema for documentaries on the sea and for an international competition on scientific cinema and marine documentaries.

Scientific, Educational and Cultural Center in the heart of the city

With the aim of strengthening the so-called "third mission", i.e. the activities of dissemination of scientific discoveries, as well as the opening of research facilities to citizens, with their direct involvement, the Darwin-Dohrn Museum offers opportunities for scientific and educational collaborations, training of teachers and specialists in the sector, educational workshops, cultural meetings, and guided tours for citizens and tourists.
The Museum was inaugurated on December 9, 2021 but its layout will be continuously enriched with new material and new initiatives.

National/International Collaborations

Italy

Altergon Italia S.r.l., Avellino, Italy
Areta International S.r.l., Milano , Italy
Biogem S.c.a r.l., Avellino, Italy
CalMED Srl, Catanzaro (CZ), Italy
Ceinge Biotecnologie Avanzate Scarl, CEINGE, Napoli, Italy
Centro Regionale di Competenza in Biotecnologie Industriali BioTekNet SCpA, Napoli, Italy
CNR, Ancona, Avellino e Roma,  Italy (Dr. Vasapollo C., Dr. GianLuigi Russo)
CNR, Avellino (G.L. Russo)
CNR, Istituto di Endocrinologia ed Oncologia Sperimentale (IEOS), Napoli, Italy
CNR, Napoli (C. Verde)
CNR-Ancona (C. Vasapollo)
CNR-Institute of Biomolecular Chemistry, Pozzuoli (A. Fontana, G. Villani, G. d’Ippolito)
ENEA-CREA La Spezia (S. Cocito, C. Lombardi, N. Lucey)
Fondazione Istituto Italiano di Tecnologia, fondazione di diritto privato, Genova, Italy
I.S.O. Istituto Superiore di Oncologia, Genova, Italy
IAMC (M. Sprovieri, S. Tamburrini, T. Alcoverro, P. Rumolo, A De Lucia)
IBAF, CNR, Legnaro (C. Calfapietra, A. Scartazza)
IBBR
IBC, CNR, Pozzuoli (G. D’Ippolito, V. Di Marzo)
IBCN CNR, Roma (C. Lanzuolo)
IBF, CNR, Pisa (C. Santinelli)
IBP-CNR. Napoli, Italy (D. DePascale)
ICB-CNR, Napoli, Italia (A. Fontana, C. Verde, G. Peluso, G. d’Ippolito, A. Cutignano)
INBIOS Srl, Napoli, Italy
INGV Napoli (G. Iannaccone)
Institute for Biomedical Technologies, ITB-CNR, Milano, Italy
ISAC, CNR, Roma (R. Santoleri)
ISMAR, Venice (M. Bastianini)
ISPRA, Livorno (I. Buttino)
ISPRA, Livorno, Italia (Dr. Isabella Buttino)
ISPRA, Livorno, Italia (I. Buttino, A. Arcancheli)
Istituto di biostrutture e bioimmagini, IBB-CNR, Napoli, Italy
Istituto per l'Ambiente Marino Costiero, Napoli, Italia (Laura Giuliano)
ITALSISTEMI S.r.l., Crotone, Italy
Novartis Vaccines & Diagnostics Srl (NVD), Messina e Siena, Italy
OGS, Trieste (A. Crise, G. Civitarese and V. Tirelli)
OKAIROS, Napoli, Italy
Primm S.r.l., Milano e Napoli, Italy
Sanofi-Aventis S.p.A., Brindisi e Milano, Italy (Dott. Tiziano Croci)
SISSA, Trieste (S. Gustincich)
Takis S.r.l., Roma , Italy
Technobiochip, S.c.a r.l., Napoli, Italy

Other Countries

Accademia Sinica, Taipei, Taiwan (Y.H. Su)
Advanced Chemistry Development Uk Limited Acd/Labs, United Kingdom
AIMS, Townsville, Australia (N. Andreakis)
Aquapharm Biodiscovery Limited Aquapharm, United Kingdom
Asociacion Instituto Nacional De Biodiversidad Inbio, Costa Rica
AWI, Bremerhaven (U. John, V. Smetacek)
Berlin Natural Museum, Berlin, Germany (E. Ullrich-Lueter)
Biobridge Limited Biobridge, United Kingdom
Biocom, Germany
Boston Children’s Hospital, USA
Boston Children’s Hospital, USA (F. Langellotto)
Centre National de la Recherche (CNRS), Observatoire Océanologique, France (Dr.  Remi Dumollard); La Rochelle, France (Dr. Lavaud J.)
Chonbuk National Univ. Jeonju, Korea (U.H. Kim)
C-Lecta Gmbh C-Lecta, Germany
CMIMA-CSIC Barcelona, Spain (J. M. Gasol, F. Peters, M. Estrada, C. Marrasé)
CNRS Montpellier, France (P. Lemaire)
CNRS, Paris, France (S. Planes)
College of Charleston USA (G. Di Tullio)
CRG, Barcelona, Spain (M. Irimia; R. Guigò)
CSIC-Blanes, Spain (Ballesteros  E., Garrabou J.)
CSIC-Blanes, Spain (E. Ballesteros, J. Garrabou, T. Alcoverro)
CSIS, Vigo, Spain (Dr. Garrido J.L.)
Dartmouth College, Hanover NH, USA (K. Peterson)
Dead Sea-Arava Science Center, Central Arava Branch, Israel (G. Winters)
Dead Sea-Arava Science Center, Central Arava Branch, Israel (Winters G.)
Deep Tek Limited, United Kingdom
DTU-Aqua, Denmark (T. Kiorboe, A. Christensen)
EAWAG Zurich, Switzerland (F. Pomati, F. Hammes)
Ecoast Research Centre Ostend Bvba Ecoast, Belgium
ELTE, Budapest, Hungary (I. Scheuring)
EMBL Heidelberg, Germany (V. Benes)
EMBL, Heidelberg, Germany (V. Benes)
ENEA-CREA La Spezia, Italy (Cocito S., Lombardi C., Lucey N.)
Fundacion Centro De Excelencia En Investigacion De Medicamentos Innovadores En Andalucia Fundación Medina, Spain (F. Reyes)
GIPREB, Etang de Berre, France (G. Bernard)
HCMR, Crete, Greece (P. Kasapidis, C. Frangoulis)
Helmholtz Centre for Environmental Research – UFZ, Leipzig, Germany (H. J. Heipieper)
Hubrecht Institute-KNAW, Utrecht, The Netherlands (S. Schulte-Merker)
IEO, Gijon, Spain (M. Latasa); IFREMER, Brest, France (R. Siano)
IEO, Palma, Spain (C. Perales Raya, J. Estefanell, E. Almansa)
Institut J. Monod, Paris France (A. Pierani)
Institute Of Microbiology, Chinese Academy Of Sciences Imcas, China
IOC of Murcia, Murcia, Spain (J.M. Ruiz Fernandez)
IPMA, Lisbon, Portugal (J. Pereira)
IRIBHM ULB, Brussels, Belgium (R. Opitz)
ISIS, Univ. de Strasbourg, France (J.M. Lehn)
Istituto De Dinamica Celular Y Biotecnologia Icdb, Chile
KTH, Stockholm, Sweden (L. Brandt)
Laboratoire Clement, Paris, France (Prof Yves Menezo)
LOV, CNRS, Villefranche, France (L. Stemmann, G. Gorsky, F. d'Ortenzio)
Lund University, Lund, Sweden (D.E. Nilsson)
Macquarie Univ, Sydney, Australia (J.M.P. Joss)
Max Planck Institute for Developmental Biology, Tuebingen, Germany (G. Jékely)
MBRC, Univ Baltimore, USA (M. Fiorentino)
Mediterranean Institute of Oceanography, Marseille, France (G. Gregori, M. Thyssen, M. Denis)
Meteorological Research Institute, Japan (M. Ishii)
MIT, Boston, USA (M. Follows)
MPI for Marine Microbiology, Bremen, Germany (F. O. Glöckner)
MPIMM Bremen, Germany (F-O.Glockner, M. Richter)
MPIMM, Bremen, Germany (F.O. Glöckner)
National Institute of Sea Sciences and Technologies, Sfax, Tunisia (N. Bradai)
Natural History Museum of Denmark, Copenhagen, Denmark (N. Lundholm)
NIOZ, Texel, Netherlands (S. Balzano)
NY University, USA (L. Christiaen)
Observatoire Océanologique de Banyuls-sur-Mer, France (H. Escriva)
Queen Mary Hospital, London, UK (M. Elphick)
RBGS, Edinburgh, Scotland, UK, (D.G. Mann)
Research Division Canadian Museum of Nature, Ottawa, Canada (M. Poulin)
RIKEN CDB, Japan (J. Pascual-Anaya, S. Kuratani)
SAHFOS, Plymouth, UK (C. Castellani and P. Licandro)
SARS, Bergen, Norway (A. Hejnol)
SBR Roscoff, France (B. Kloareg, N. Simon, I. Probert, D. Vaulot, F. Not, C. De Vargas)
Sealife Pharma Gmbh, Austria (A. Pretsch)
Stanford University, CA USA (F. Micheli)
Station Biologique de Roscoff, Roscoff, France (S. Mazan)
TGAC, Norwich, UK (M. Caccamo)
The Royal Society of Chemistry Rsc, United Kingdom
Tohoku Univ. Asamushi, Japan (K. Kyozuka)
Union Internationale Pour La Conservation De La Nature Et De Ses Ressources Iucn Elc, Switzerland
Univ Adelaide, Australia (M. Lardelli)
Universitat Barcelona, Barcelona, Spain (P. Martinez; G. Fernández)
University College London, London, UK (P. Olivieri)
University of Bath, UK (R. Kelsh)
University of California, USA, (N. Holland)
University of Koln, Germany (M. Hammerschmidt)
University of Murcia, Murcia, Spain (L. Puelles; J.L. Ferran)
University of Washington, USA (B.J. Swalla)
UPMC-CNRS, Villefranche-sur-mer, France (S. Tiozzo, C. Hudson, H. Yasuo, R. Dumollard)
UPO, Siviglia, Spagna (J.R.M. Morales)
Vienna University, Vienna, Austria (U. Technau)
Zoologisches Forschungmuseum A. Koenig, Bonn, Germany (T. Krapp-Schickel)

Collaborations with Universities

Italian Universities

Seconda Università di Napoli, Napoli, Italy
U. Politecnico di Milano, Milano, Italy (P. Melià e R. Casagrandi)
UNICAL, Cosenza, Italy (I. Serra)
UniParthenope, Napoli Italy (G. F. Russo)
Univ. Di Messina, Messina, Italy (L. Guglielmo)
Univ. Federico II, Napoli, Italia (S. Cozzolino, C. Agnisola, G. Guerriero, A. Amoresano, L. Tutino, V. Costantini, O. Mangoni)
Univ. of Naples, Caserta, Italy (M. De Stefano)
Univ. of Pisa, Pisa, Italy (F. Bulleri, P. Luchi)
Univ. of Roma ’Tor Vergata’, Roma, Italy (L. Migliore)
Univ. of Sassari, Italy (G. Ceccherelli)
Univ. of Verona, Verona, Italy (M. Delle Donne)
Univ. Padova, Padova, Italy (L. Zane)
Univ. Roma, "La Sapienza"” Rome, Italy (S. Espa)
Università degli studi della Calabria, Rende, Italy (A. Gattuso, M.C. Cerra)
Università degli studi di Padova, Padova, Italy (F. Cima)
Università degli studi di Parma, Parma, Italy (P. Ferrari, L. Fogassi)
Università degli Studi di Salerno, Salerno, Italy (A. Weisz)
Università degli studi di Trento, Trento, Italy (I. Mancini, G. Vallortigara)
Università degli Studi Magna Graecia di Catanzaro, Catanzaro (CZ) , Italy
Università del Salento, Lecce, Italy (Prof. Giangrande A., Lezzi M.)
Università del Sannio, Benevento, Italy (L. Canzoniero, L. Cerulo, M. Ceccarelli)
Università della Basilicata, Italia (Prof. Raffaele Boni)
Università della Basilicata, Italy (R. Boni)
Università di Bari, Bari, Italy (G. Pesole)
Università di Bologna, Bologna (Prof.s Colangelo M.A., Ceccherelli V.U., Goffredo S.)
Università di Genova, Italy (Prof. Canesi L.)
Università di Messina, Messina, Italy
Università di Milano –Bicocca, Milano, Italy
Università di Napoli Federico II, CRIACQ (Portici), Italy (Dr. Graziani G.)
Università di Napoli Federico II, Dipartimento di Farmacia,  Napoli, Italia (Valeria Costantino)
Università di Palermo, Palermo, Italy (Vizzini T., Ricevuto E.)
Università di Salerno, Fisciano, Italy (Dr. Caruso T., Dr. Dal Piaz F.)
Università di Siena, Siena, Italy
Università Federico II, Napoli, Italia (C. Arena, L. Corsaro, G. Graziani, A. Amoresano, L. Tutino)
Università Federico II, Napoli, Italy (V. Costantino, L. Cigliano, A. Donizetti, C. Agnisola, L. Fucci, F. Aniello, G. De Vita, G. Guerriero)
Università la Sapienza, Roma, Italy (M. Toni, M. Oliverio)
Università Parthenope, Napoli, Italy (Prof. Russo G.F.)
Università Politecnico delle Marche, Ancona, Italy (Prof. Regoli F.)
University of Bologna: Prof.s Colangelo M.A., Ceccherelli V.U., Goffredo S.
University of Genoa, Genoa, Italy (S. Zupo, P. Rivaro)
University of Palermo, Palermo, Italy (S Lo Brutto)
University of Palermo, Palermo, Italy (T. Vizzini, E. Ricevuto)
University of Salento - Lecce: Prof. Giangrande A., Lezzi M.
University Parthenope, Napoli, Italy (G.F. Russo, M. Uttieri, E. Zambianchi)
University Politechniche delle Marche – Ancona, Italy (F. Regoli, A. Pusceddu)

Foreign Universities

Danmarks Tekniske Universitet Dtu, Denmark
ECIM, Universidad Cattolica de Chile; Chile (P. von Dassov)
ENS, Paris, France (C. Bowler, S. Speich)
EULA Center, Universidad de Concepción, Chile (V. Aguilera Ramos)
Hopkins Marine Station - Stanford University, Ca, USA (Prof. Micheli F.)
Institute of Marine Biology, National Taiwan Ocean University, Keelung, Taiwan (Jiang-Shiou Hwang)
Katholieke Universiteit Leuven K.U., Leuven, Belgium
Lund University, Lund, Sweden (G. Bianco)
National Taiwan Ocean University, Keelung, Taiwan (Jiang-Shiou Hwang)
Princeton University, Princeton, USA (K.B. Rodgers)
RUG, Groningen, The Netherlands (J. L. Olsen)
Technical University of Denmark (DTU) Denmark (T. Ostenfeld Larsen)
Technical University of Denmark (DTU). Lyngby, Denmark (T. Ostenfeld Larsen)
The University Court Of The University Of Aberdeen Uniabdn, United Kingdom (M. Jaspars)
UEA, Norwich, UK (T. Mock)
Univ. Arizona, Tucson, USA (M. Sullivan)
Univ. Barcelona, Spain (J. Romero, C. Canestro)
Univ. of Algarve, Faro, Portugal (J. Silva and R. Santos)
Univ. of Bilbao, Bilbao, Spain (A. Estomba)
Univ. of Maine, Orono, USA (E. Boss, L. Karp-Boss)
Univ. of Nizza, France (L. Mangialajo)
Univ. of Stockholm, Sweden (R. Caballero, M. Bjork)
Universidad Austral de Chile, Valdivia (H. González)
Universidade De Santiago De Compostela Usc, Spain
Università di Pamukkale e DEKAMER Sea Turtle Research Centre, Dalyan, Mugla, Turchia, (Y. Kaska)
Université de Sfax, Sfax, Tunisia (K. Belghith)
Universitetet I Tromsoe Uot,  Norway (J. Andersen)
University Ben Gurion, Beer Sheva, Israel (A. Sagi)
University California Santa Cruz, Ca, USA (K. Kroeker)
University College Cork, National University Of Ireland, Cork Ucc, Ireland (A. Dobson)
University of Barcelona, Barcelona, Spain (C. Canestro)
University of California Santa Cruz, Ca, USA (Kroeker K.)
University of Concepción, Concepcion, Chile (C. Lange)
University of Ghent, Ghent, Belgium (W. Vyverman, K. Sabbe, O. DeClerck, L. Clement)
University of Goteborg, Goteborg, Sweden (A. Godhe, E. Selander, L. Turner)
University of Goteborg, Sweden (Turner L.)
University of Helsinki, Helsinki, Finland (A. Kremp)
University of Koeln. Koeln, Germany (E. von Elert)
University of Malta, Malta (J-A. Borg)
University of Massachusetts Dartmouth, USA (J.T. Turner)
University of Massachusetts, Dartmouth, USA (J. T. Turner)
University of Quebec Rimouski, Canada (Calosi P.)
University of Rio del Janeiro, Argentina (M. Bastos)
University of Tasmania, Hobart, Australia (E. Graham)
University Of The Western Cape Uwc South Africa
University of Trento, Italy (Prof. Ines Mancini)
University of Vigo, Vigo, Spain (Dr. Fernandez  F.)
University Of Waikato Uow, New Zealand
University of Wien. Vienna, Austria (K. Wittmann)
University of Zagreb, Zagreb, Croatia (S. Bosak)
University of Zurich. Zurich, Switzerland (F. Jüttner)
University Quebec Rimouski, Canada (P. Calosi)
University Queen Mary, London, UK (Prof. Ruban A.V.)
UPMC, Paris, France (A. Falciatore)
Wuhan University Whu, China