Animal evolution from a cell type perspective: multidisciplinary training in single-cell genomics, evo-devo and in science outreach

Summary

The aim of EvoCELL is to lay the foundation for a new branch of evo-devo focussing on cell types. We will study fundamental questions in animal evolution and development - eg. how new cell types arise in evolution, how many are in common between different animal groups and how many unique cell types have evolved in different animal lineages- using a new technology, single cell sequencing, which we will for the first time employ outside of lab models to sample the great diversity of animal phyla. EvoCELL will train a new generation of multidisciplinary scientists skilled in exploring the vast breadth of animal differentiation. We will jointly sample data from all major animal lineages, richly represented in the biodiversity of European waters, and develop new tools for comparative analyses, through which we will together pioneer three branches of cell evo-devo: evolution of stem cells; emergence of animal life cycles, and the stunning diversity of neural cell types. Through their excellent interdisciplinary and intersectoral training, from single-cell biology and palaeontology to bioinformatics and public outreach, our graduates will be in prime positions to assume leadership roles in academia, industry, and science outreach.

What we do

We are one of ten partners and are contributing to the diversity and evolution of neuronal cell types.

Partners

European Molecular Biology Laboratory, Heidelberg - DE; Stazione Zoologica Anton Dohrn, Napoli – IT; Uppsala University, Uppsala – SE; University of Heidelberg, Heidelberg – DE; University of Exeter, Exeter - UK; University College London, London – UK; Sars International Center for Marine Molecular Biology, Bergen – NO; Centre National de la Recherche Scientifique, Villefranches sur mer, Lion - FR; Non-academic partners: Museum für Naturkunde, Berlin – DE; Genomix4Life, Salerno - IT

Research Area

Organismal Biology

Project Lifetime

January 2018 to December 2022

SZN Role

Partner

Principal Investigator

Maria I. Arnone

People involved

2 ESRs to be hired

Funding Institution

European Commission, Horizon 2020 Call for Proposal: H2020-MSCA-ITN-2017. Grant Agrement no. 766053.

Contribution to SZN

€344081,76 (EU contribution)

Dedicated website

https://www.evocell-itn.eu/

Media - Pictures

Meet the team

Maria I. Arnone, Researcher
Periklis Paganos, PhD student

Coordinated Research Infrastructures Building Enduring Life-science Services

Summary

CORBEL is an initiative of thirteen new biological and medical research infrastructures (BMS RIs), which together will create a platform for harmonised user access to biological and medical technologies, biological samples and data services required by cutting-edge biomedical research. CORBEL will boost the efficiency, productivity and impact of European biomedical research. Individually, the services offered by the BMS RIs are critical to their own user communities. Collectively, through CORBEL, they will be transformative across the range of life-science disciplines: from generation of knowledge at the bench to patient treatment at the bedside.

What we do

The SZN participate to the WP4 (Community Driven Cross-Infrastructure joint research – Bioscience): Use case 4 (Marine Metazoan Developmental Models for BioMedical research - from predictive integrated databases to functional testing), coordinated by CNRS-Villefrances-sur-Mer (Evelyn Houliston). Within this WP the SZN hired for 18 mo the bioinformatician postdoc Elijah K. Lowe to work at enabling genomics and databases for Paracentrotus lividus.

Partners

Altogether, the CORBEL consortium comprises 37 individual partner institutions from 13 ESFRI Biological and Medical Sciences Research Infrastructures (BMS RI). Partners within WP4 are: EMBL-HD, EMBL-EBI, UMCU, ICFO, CRG, BRFAA, HMGU, CIRMMP, CSIC, CNRS, SZN, USTAN, FVB, MDC, VU/VUmc, DKFZ.

Research Area

Research Infrastructure

Project Lifetime

September 2015 to August 2019

SZN Role

Partner

Principal Investigator

Maria I. Arnone

People involved

Elijah K. Lowe - Salvatore D’Aniello - Anna Palumbo - Filomena Ristoratore

Funding Institution

European Commission Horizon 2020 research and innovation programme. Grant agreement No 654248.

Contribution to SZN

€90.700,00. (EU contribution)

Dedicated website

http://www.corbel-project.eu/home.html

Media - Pictures

Corbel Twitter

Corbel You tube channel

Summary

ASSEMBLE Plus is a consortium of marine biological research stations in 16 countries, operating under the umbrella of the European Marine Biological Resource Centre (EMBRC-ERIC). The consortium provides scientists from academia, industry and government with transnational access to its marine biological research facilities, its historical data, and to advanced training opportunities, ASSEMBLE Plus aims to stimulate fundamental and applied research excellence in marine biology and ecology in Europe.

What we do

The 39 partner stations in the consortium provide access to a wide range of marine ecosystems, including the Red Sea, the Caribbean and Svalbard. We aim at attracting not only marine biological projects but also ones from non-marine sciences and from the private sector. We further aim to improve service provision by developing novel technologies and data solutions. Access to our stations is Trans-National, meaning that you can access ASSEMBLE Plus stations in any partner country other than the country in which you are employed.
If you wish to make use of this access program, you need to submit a short research proposal, and if this is selected, you will be able to carry out your proposed research at a marine partner station of your choice. The expenses of your stay as well as your travel costs will be covered, within certain limits, by ASSEMBLE Plus. If you are employed outside the EU, you can make use of the access program as well, but some restrictions apply.
For more information on ASSEMBLE Plus, including information on calls for proposals, rules, application- and access procedures, and submission deadlines, see http://www.assembleplus.eu. For any specific questions, contact Access Officer Florence Guillot; Email: access (at) embrc.eu

Partners

ASSEMBLE Plus Access Providers in the European Marine Biological Resource Centre (EMBRC-ERIC) are:
• EMBRC-Belgium (VLIZ, UGENT),
• EMBRC-France (Sorbonne Universités, CNRS),
• EMBRC-Greece (HCMR),
• EMBRC-Israel (HUJI),
• EMBRC-Italy (SZN, CNR),
• EMBRC-Norway (UiB),
• EMBRC-Portugal (CCMAR, IMAR, CIIMAR),
• EMBRC-Spain (UPV/EHU, UVIGO),
• EMBRC-UK (SAMS, USTAN, MBA, NERC-BAS, MSS),

ASSEMBLE Plus Access Providers not currently member of EMBRC-ERIC:
• Finland (UH),
• Germany (AWI, MPIMM),
• Ireland (NUIG),
• The Netherlands (NIOZ),
• Poland (IOPAN, UG-Gdansk),
• Slovenia (NIB),
• Sweden (UGOT – SLC).

Detailed information on the Access Providers is available on the ASSEMBLE Plus website at http://www.assembleplus.eu/

This distributed partnership provides access to diverse marine ecosystems and their biodiversity of the European coastal seas, the Red Sea (HUJI), the Caribbean (NIOZ), the Arctic (IOPAN) and the Antarctic (NERC-BAS).

Research Area

Research Infrastructure

Project Lifetime

48 months as of 1 October 2017

SZN Role

The SZN lead the Work Package “NA1 Improving Transnational Access (TA) provision”, coordinating the input from UPMC, UGOT, UPV/EHU, CCMAR, VLIZ, MSS.
The main objectives are:
• Establish a policy for regulating, granting and supporting TA;
• Set up single-access point for TA to the offered infrastructure;
• Test TA-pipelines through ASSEMBLE Plus and cognates in joint calls;
• Share best practices among platforms and services;
• Improve the efficiency of TA service provision.

SZN is involved as partner in three Joint Research Activities (JRAs).
JRA1 Genomics observatories
JRA3 Functional genomics
JRA4 Development of instrumentation

TA: In Italy, the SZN coordinates the transnational access to SZN in Naples and Ischia and to its Third Parties ISMAR-CNR in Venice http://www.ismar.cnr.it and IAMC-CNR in Messina http://www.iamc.cnr.it/index.php/contattaci/). All give access to Mediterranean pelagic and benthic hard- and soft bottom ecosystems.

SZN includes the main building in the Villa Comunale in Naples, the benthic ecology laboratory at Ischia Porto and the turtle research centre at Portici. Visitors have access to service platforms and research laboratories. SZN does not operate a guesthouse given ample supply of hotels and B&Bs nearby. SZN has extensive experience with collecting and maintaining model species and performing multi- disciplinary research on these organisms http://www.szn.it/index.php/en/research

Principal Investigator

Wiebe H.C.F. Kooistra

Funding Institution

Université Sorbonne coordinates the project.

Contribution to SZN

€ 1.017.745,25 of which € 289.702,00 to the Third Parties

Dedicated website

http://www.assembleplus.eu/