Finanziato dal Programma Operativo ENPI CBC Mediterranean Sea Basin 2007/2013 dell’Unione Europea
Responsabile Scientifico Raffaella Casotti

Il progetto è indirizzato a fornire il necessario sostegno tecnico e organizzativo, soprattutto alle piccole e medie imprese (esistenti e potenziali) che operano nel settore agro-alimentare e in altri settori tradizionali del turismo, per la promozione di azioni coordinate volte ad aumentare la quota dei proventi del turismo che avvantaggia le economie dei paesi del Mediterraneo. Il risultato principale del progetto riguarda la creazione di nuove attività imprenditoriali legate al turismo sostenibile in quattro aree costiere dotate di notevoli risorse naturali e culturali e il potenziamento di alleanze di imprese attraverso l'adozione di un approccio di gestione pubblica/privata, standard di qualità e incentivare sistemi in cui sono accoppiati gli obiettivi di sviluppo economico con la protezione e la valorizzazione del patrimonio naturale/culturale.
Inoltre, il progetto creerà una rete internazionale di destinazioni  di turismo costiero sostenibile nel bacino del Mar Mediterraneo come luogo per lo sviluppo di metodologie comuni durante l’attuazione del progetto e nel lungo periodo quali il monitoraggio e la piattaforma promozionale partecipata da utilizzatori locali, nazionali e scientifici e aperto ai nuovi soggetti, che potrebbe stimolare ulteriori sviluppi di turismo costiero sostenibile sulla rotta del Mediterraneo.

Siamo partner del progetto ed il nostro ruolo è di creare il sistema di monitoraggio dei tre siti al fine di a) fornire dati in tempo reale sulle condizioni ambientali b) sensibilizzare i visitatori alle tematiche ambientali, diffondendo la cultura sceintifica anche attraverso azioni di "citizen science" c) formare gli operatori turistici affinchè siano coscienti del valore ambientale dei loro siti e partecipino alla loro valorizzazione e conservazione

Partners: il Ministero dei beni e delle attività culturali e del turismo (Coordinatore), la Penisola di Sinis (Sardegna), la Stazione Zoologica Anton Dohrm, la municipalità di Mahdia (Tunisia) e l’Istituto Nazionale di Scienze Marine e Tecnologia della Tunisia, la Al-Balqa Applied University e l’Area Marina protetta di Aqaba (Giordania)

Gut patterning and PANcreas development in evolution and disease: a TRAnsCriptomic approach

Summary

Many genes that have been shown to cause diseases were originally identified because of their role in embryonic development, but were subsequently shown to be also important in the postnatal control of cell growth and differentiation. This is the case of many transcription factors (TF) among which the ParaHox gene Xlox, whose mammalian homolog, Pdx1, is well known for its role in specification of the pancreas, and subsequent formation and maintenance of pancreatic beta-cells. Pdx1 is a causal factor in the development of diabetes, wherein there is a deficiency in insulin production of beta-cells within the pancreas. Moreover, mis-expression of Pdx1 is commonly seen in intestinal disorders such as Crohn’s disease. Here we propose to combine analyses in the highly simple but phylogenetically relevant sea urchin embryo and sea star embryo models with developmentally targeted mouse transcriptome data to characterize regulatory connections that are downstream of the disease-related Xlox/Pdx1 transcription factor.

What we do

We are coordinator of the project and Operating unit SZN and will perform all manipulations and analyses in sea urchin and sea star embryos and all bioinformatic analyses and evolutionary comparisons.

Partners

Stazione Zoologica Anton Dohrn, Napoli; Laboratorio di Medicina Molecolare e Genomica, Università degli Studi di Salerno.

Research Area

Organismal Biology

Project Lifetime

April 2014 to December 2015

SZN Role

Coordinator

Principal Investigator

Maria I. Arnone

Funding Institution

MIUR Progetti Premiali (DLGS 213/99)

Contribution to SZN

€169.143,00 (MIUR contribution)

Publications

Annunziata R and Arnone MI (2014). A dynamic network of regulatory interactions explains ParaHox gene control of gut patterning in the sea urchin embryo. Development 141: 2462-72.

Perillo M, Wang YJ, Leach SD and Arnone MI. Specification and differentiation of pancreatic, acinar-like cells in the sea urchin embryo and larva. Submitted to Development.

Meet the team

Maria I. Arnone, primo ricercatore
Rossella Annunziata, postdoc
Claudia Cuomo, PhD student
Elijah Lowe, postdoc

Multidisciplinarity training in evo-devo and neurobiology of marine animal models

Summary

Neptune is a multidisciplinary training network in evo-devo and neurobiology of marine animal models. Through the use of advanced methods of genetic analysis and imaging technologies, Neptune aims at solving an array of important questions in the evolution, development, neurobiology and ecology of marine invertebrates.
Neptune is training a new generation of young researchers by combining the strengths of modern technologies with a real understanding of traditional approaches. The Neptune consortium involves seven academic institutions and one industrial partner that will provide Neptune fellows with expertise, specialized equipment and training on a wide range of approaches and methodologies incorporated in evolutionary developmental biology and marine neurobiology.

What we do

We are one of the seven partners and are contributing to the WP "Evolution of sensory systems" by studying photoreceptor evolution in echinoderms and hemichordates (Ambulacraria).

Partners

European Molecular Biology Laboratory, Heidelberg - DE; Stazione Zoologica Anton Dohrn, Napoli – IT; Uppsala University, Uppsala – SE; Max Plank Institute for Developmental Biology, Tübigen – DE; University College London, London – UK; Sars International Center for Marine Molecular Biology, Bergen – NO; Centre National de la Recherche Scientifique, Villefranches sur mer, Lion - FR; Associate industrial partner: ZEISS.

Research Area

Organismal Biology

Project Lifetime

March 2013 to February 2017

SZN Role

Partner

Principal Investigator

Maria I. Arnone

Funding Institution

European Commission, FP7 Call for Proposal: FP7-PEOPLE-2012-ITN
Marie Curie Action - Initial Training Network (ITN)
Grant no. 317172

Contribution to SZN

€302.697,45 (EU contribution)

Dedicated website

http://neptune-itn.eu

Media - Pictures

Neptune facebook group

Publications

Valero-Gracia A, Petrone L, Oliveri P, Nilsson DE, Arnone MI. Non-directional Photoreceptors in the Pluteus of Strongylocentrotus purpuratus Frontiers in Ecology and Evolution (2016) 4, 127.

D’Aniello S, Delroisse J, Valero-Gracia A, Lowe EK, Byrne M, Cannon JT, Halanych KM, Elphick MR, Mallefet J, Kaul-Strehlow S, Lowe CJ, Flammang P, Ullrich-Lüter E, Wanninger A and Arnone MI (2015). Opsin evolution in the Ambulacraria. Marine Genomics, 24: 177-183.

Ullrich-Lüter E, D’Aniello S and Arnone MI (2013). C-opsin expressing photoreceptors in echinoderms. Integr Comp Biol 53: 27-38.

Peterson KJ, Su Y-H, Arnone MI, Swalla B, and King B (2013). microRNAs Support the Monophyly of Enteropneust Hemichordates. J Exp Zool B Mol Dev Evol 320: 368-374.

Meet the team

Maria I. Arnone, primo ricercatore
Alberto Valero Gracia, PhD student

Marie Curie Career Integration Grant (FP7-PEOPLE-2011-CIG)

Summary

The main interest of the project is to study the Nitric Oxide Synthase (NOS) family evolution and its regulation during amphioxus development. In the framework of the project, setting-up an amphioxus facility at the SZN was a priority of national interest, representing the first Italian laboratory working with live amphioxus embryos on demand.
Since Furchgott, Ignarro and Murad won the Nobel Prize in Medicine or Physiology in 1998 for their breakthrough work on the role of nitric oxide (NO) as a multifunctional signaling molecule, many reports have shown the seemingly limitless range of body functions controlled by this compound. To manipulate the endogenous NO level for therapeutic benefits using NOS gene therapy is essential to understand the physiological and developmental functions of different NOS isoforms (nNOS, iNOS, eNOS). Due to their extensive conservation over evolutionary time, one would expect greater differences and structural changes in NOS genes than that we have observed (Andreakis 2011), reflecting the very ancient and essential nature of Nitric Oxide biological pathways.
Surprisingly, a single molecule, identical in all living animals, can fulfil a huge range of different functions. This suggests that differences in the regulation of NOS enzymes expression are key in explaining their functional diversification, functional novelties and degree of complexity.

What we do

We use as animal model system the cephalochordate amphioxus Branchiostoma lanceolatum, from the Gulf of Napoli (Italy) and from Banyuls-sur-Mer (France), with comparative and multidisciplinary approaches in the field of Evolutionary and Developmental Biology (Evo-Devo). The primary aim of this project is to perform a detailed study of the duplicated set of NOS genes during amphioxus development, trying to establish the basic primary NOS roles that are evolutionary conserved in chordates.

Partners

Stazione Zoologica Anton Dohrn, Napoli.

Research Area

Organismal Biology

Project Lifetime

August 2011 to July 2015

SZN Role

Coordinator

Principal Investigator

Salvatore D’Aniello

Funding Institution

European Commission, FP7 Call for Proposal: FP7-PEOPLE-2011-CIG
Grant no. 293871

Contribution to SZN

€100.000 (EU contribution)

Dedicated website

http://cordis.europa.eu/project/rcn/99685_en.html

Publications

Coppola U, Annona G, D’Aniello S* and Ristoratore F* (2015). Rab32/38 duplicated genes in chordate pigmentation: an evolutionary perspective BMC Evolutionary Biology, under review.

Annona G, Holland ND* and D’Aniello S* (2015). Evolution of the notochord. EvoDevo, in press.

Anishchenko E and D’Aniello S* (2015). Tunicate neurogenesis: the case of the SoxB2 missing CNE. Mathematical Models in Biology (Springer), in press.

Vassalli QA, Anishchenko E, Caputi L, Sordino P, D'Aniello S* and Locascio A* (2015). Regulatory elements retained during chordate evolution: Coming across tunicates. Genesis 53: 66-81.

Pascual-Anaya J, D’Aniello S, Kuratani S and Garcia-Fernàndez J (2013). Evolution of the Hox clusters in deuterostomes. BMC Developmental Biology 13: 26.

Meet the team

Salvatore D’Aniello, Ricercatore    
Evgeniya Anishchenko, post-doc
Giovanni Annona, post-doc
Filomena Caccavale, PhD student