Empowering an integrated platform for the study of human diseases with great impact by means of system phenotyping of model animals: mouse and zebrafish clinic (MouZeCLINIC).
Summary
MouZeCLINIC is an infrastructural and training network in biomedicine by means of acquatic and terrestrial model organisms. Through the use of advanced methods of genetic analysis and imaging technologies, MouZeCLINIC aims at performing system phenotyping in zebrafish and mouse models of human diseases. MouZeCLINIC is training a new generation of young researchers by combining the strengths of modern technologies with a real understanding of traditional approaches. The MouZeCLINIC consortium involves two research centers and one academic institution that will provide the MouZeCLINIC fellows with expertise, specialized equipment and training on a wide range of approaches and methodologies incorporated in developmental genetics and translational medicine.
What we do
We are one of the three partners and are contributing by training students, by developing a zebrafish infrastructure and by studying fish models of neuroinflammation, toxicity and metabolism.
Partners
BioGem scarl – Ariano Irpino (Avellino) - IT; Stazione Zoologica Anton Dohrn, Napoli – IT; Università della Magna Graecia – Germaneto (Catanzaro) - IT
Research Area
Organismal Biology
Project Lifetime
January 2012 to July 2015
SZN Role
Partner
Principal Investigator
Funding Institution
Ministero dell’Istruzione dell’Università e della Ricerca (MIUR):
Programma Operativo Nazionale - ”Ricerca e Competitività” 2007-2013
Grant no. PONa3_00239
Contribution to SZN
Infrastructure € 1.273.424,00 (MIUR contribution)
Training € 733.670,00 (MIUR contribution)
Dedicated website
http://www.ponrec.it/open-data/risultati/potenziamento-strutturale/pona3_00239
Publications
Pappalardo A, Porreca I, Caputi L, De Felice E, Schulte-Merker S, Zannini M, Sordino P (in press) Thyroid development in zebrafish lacking TAZ. Mechanisms of Development.
Fortunato AE, Sordino P, Andreakis N (in press) Evolution of the SOUL heme-binding protein superfamily across Eukarya. J Molecular Evolution.
Porreca I, D’Angelo F, Gentilcore D, Carchia E, Amoresano A, Affuso A, Ceccarelli M, De Luca P, Esposito L, Guadagno FM, Mallardo M, Nardone A, Maccarone S, Pane F, Scarfò M, Sordino P, De Felice M, Ambrosino C (2014) Cross-species toxicogenomic analyses and phenotypic anchoring in response to groundwater low-level pollution. BMC Genomics 15: 1067.
De Felice E, Porreca I, Alleva E, De Girolamo P, Ciriaco E, Germanà A, Sordino P (2014) Localization of BDNF expression in the developing brain of zebrafish. Journal of Anatomy 224: 564.
Ferriero R, Manco G, Lamantea E, Nusco E, Ferrante MI, Sordino P, Stacpoole PW, Lee B, Zeviani M, Brunetti-Pierri N (2013) Phenylbutyrate therapy for pyruvate dehydrogenase complex deficiency and lactic acidosis. Science Transl Med, 5 (175): 175ra31.
Porreca I, De Felice E, Fagman H, Di Lauro R, Sordino P (2012) Zebrafish bcl2l is a survival factor in thyroid development. Developmental Biology 366:142.
Meet the team
Paolo Sordino, ricercatore
