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Marine Biotechnology Department

Tel.: +39 0815833321
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Contatto Skype: coppola_daniela

Curriculum Vitae

Research Interests

The research activity is focused on two main research lines.
The first one is the study of biological processes in polar ecosystems to define tolerance limits and adaptation mechanisms to extreme environments.
Biochemical characterisation of haemoproteins from marine organisms, such as fish and bacteria, is a source of invaluable information for the cold adaptation.
In particular, the study is focused on (i) the search of structural determinants able to confer the peculiar properties of these proteins, and (ii) the identification of their physiological role, paying particular attention to the involvement in nitrosative stress.
The second research interest is based on marine biotechnology.
In particular, new research lines involve: (i) the exploration of microbial marine biodiversity in order to isolate microorganisms with high antioxidant activity and ability to resist to ultraviolet radiations, to identify new bioactive compounds and enzymes with potential nutraceutical, cosmeceutical and pharmaceutical applications, and (ii) the sustainable and efficient exploitation of the underused marine raw materials of the Mediterranean Sea, to develop new products of commercial interest, with a significantly reduced impact on the environment.

Selected Publications

Bruno S, Coppola D, di Prisco G, Giordano D, Verde C (2019). Enzymes from marine polar regions and their biotechnological applications. Marine Drugs, 17: 544.

Giordano D, Costantini M, Coppola D, Lauritano C, Núñez Pons L, Ruocco N, di Prisco G, Ianora A, Verde C (2018). Biotechnological applications of bioactive peptides from marine sources. Advances in Microbial Physiology, 73: 171-220.

Coppola D, Giordano D, Milazzo L, Howes BD, Ascenzi P, di Prisco G, Smulevich G, Poole RK, Verde C (2018). Coexistence of multiple globin genes conferring protection against nitrosative stress to the Antarctic bacterium Pseudoalteromonas haloplanktis TAC125. Nitric Oxide, 73, 39-51.

Feis A, Howes BD, Milazzo L, Coppola D, Smulevich G (2018). Structural determinants of ligand binding in truncated hemoglobins: resonance Raman spectroscopy of the native states and their carbon monoxide and hydroxide complexes. Biopolymers, e23114.

Giordano D, Coppola D, Russo R, di Prisco G, Denaro R, Giuliano L, Lauro F, Verde C (2015). Marine microbial secondary metabolites: pathways, evolution and physiological roles. Advances in Microbial Physiology 66: 357-428.

Coppola D, Giordano D, Abbruzzetti S, Marchesani F, Balestrieri M, di Prisco G, Viappiani C, Bruno S, Verde C (2015). Functional characterisation of the haemoglobins of the migratory notothenioid fish Dissostichus eleginoides. Hydrobiologia, Biology of the Ross Sea 761: 315-333.

Giordano D, Russo R, Coppola D, Altomonte G, di Prisco G, Bruno S, Verde C (2015). “Cool” adaptations to cold environments: globins in Notothenioidei. Hydrobiologia, Biology of the Ross Sea 761: 313.

Coppola D, Giordano D, Tinajero-Trejo M, di Prisco G, Ascenzi P, Poole RK, Verde C (2013). Antarctic bacterial hemoglobin and its role in the protection against nitrogen reactive species. Biochimica et Biophysica Acta, 1834, 1923-1931.

Coppola D, Abbruzzetti S, Nicoletti F, Merlino A, Gambacurta A, Giordano D, Howes BD, De Sanctis G, Vitagliano L, Bruno S, di Prisco G, Mazzarella L, Smulevich G, Coletta M, Viappiani C, Vergara A, Verde C (2012). ATP regulation of the ligand-binding properties in temperate and cold-adapted haemoglobins. X-ray structure and ligand-binding kinetics in the sub-Antarctic fish Eleginops maclovinus. Molecular BioSystems 8, 3295-3304.

Coppola D, Bruno S, Ronda L, Abbruzzetti, Viappiani C, di Prisco G, Verde C, Mozzarelli A (2011). Low affinity PEGylated hemoglobins from Trematomus bernacchii, a model for hemoglobin-based blood substitutes. BMC Biochemistry 12, 66. doi:10.1186/1471-2091-12-66.

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