Ph. D. Student
Department of Eco-sustainable Marine Biotechnology
Stazione Zoologica Anton Dohrn Villa Comunale
80121 Naples - Italy
Tel.: +39 3386410300
E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
SZN Supervisors: Maria Costantini and Valerio Zupo
UNINA Supervisor: Prof. Francesco Loreto
Program: National PhD Course “Research in Artificial Intelligence, Area of Specialization Agrifood and Environment, University of Naples Federico II, 40° cycle
Research Interests
Among the various forms of programmed cell death (PCD), ferroptosis is characterized by the involvement of redox-active iron and the accumulation of reactive oxygen, nitrogen, and lipid species, highlighting oxidative stress as a key triggering mechanism. Similarly, natural compounds such as isoprene exhibit significant antioxidant properties, counteracting oxidative stress and providing protection against abiotic stressors. The application of artificial intelligence (AI) techniques is revolutionizing the understanding of these mechanisms by analyzing complex datasets and fostering the development of novel biotechnologies.
This project investigates the role of isoprenoids, extracted from marine benthic diatoms, as antagonists of oxidative stress and ferroptosis. Ferroptosis will be studied across different evolutionary levels to better understand the conservation and significance of this process along the evolutionary scale, using various marine organisms as models. Advanced AI techniques will be used to analyze evolutionary relationships between oxidative stress and ferroptosis.
Selected Publications
Maione A., Mileo A., Pugliese S., Siciliano A., Cirillo L., Carraturo F., de Alteriis E., De Falco M., Guida M., Galdiero E. (2023), VT-1161—A Tetrazole for Management of Mono-and Dual-Species Biofilms, Microorganisms Mdpi
Pugliese S., Padilla Suarez E.G., Galdiero E., Guida M., Libralato G., Saviano L., Spampinato M., Pappalardo C., Siciliano A. (2023), Multigenerational test on Daphnia spp: a vision and new perspectives, environmental pollution 337, 122629
