EMI
EMI
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sirakov newResearcher
Biology and Evolution of Marine Organisms Department

Tel.: +39 081 5833324
Fax: +39 081 7641355
e-mail: maria.sirakov(at)szn.it
Skype: This email address is being protected from spambots. You need JavaScript enabled to view it.
ORCID:
https://orcid.org/0000-0001-5321-6794

Curriculum Vitae

EXPERTISE KEYWORDS Intestinal Stem Cells, Signalling pathways, Colorectal Cancer, Marine Organisms, Gene expression

Research Interests

I am a natural scientist with expertise in developmental biology and molecular biology. My interest in developmental biology ranges from the biological processes involved in development, stemness or homeostasis to the degeneration of molecular players resulting in pathological processes such as cancer. Currently, I am involved in studies of the anthropic impact on marine organisms (considering both ecological and human health aspects), looking also at the digestive system of non-vertebrate marine models. A comparative and evolutionary approach using of non-vertebrate marine animals as model systems is absolutely complementary to the knowledge of the vertebrate/mammalian systems. Finally, to study the biology of marine organism could provide also biological sources for bioactive compounds or macromolecules

Selected Publications

• Salatiello F, Gerdol M, Pallavicini A, Locascio A, Sirakov M* (2022) Comparative analysis of novel and common reference genes in adult tissues of the mussel Mytilus galloprovincialis. BMC Genomics 23:349 doi: 10.1186/s12864-022-08553-1

• Pontoni L, La Vecchia C, Boguta P, Sirakov M, D’Aniello E, Fabbricino M, Locascio A (2022) Natural organic matter controls metal speciation and toxicity for marine organisms: a review. Environ Chem Lett, 20: 797–812. doi:10.1007/s10311-021-01310-y

• Sirakov M, Plateroti M. Thyroid Hormone Signaling and Function: News from Classical and Emerging Models. Cells (2022) 11:453. doi:10.3390/cells11030453

• Sirakov M*, Claret L, Plateroti M. Thyroid Hormone Nuclear Receptor TRα1 and Canonical WNT Pathway Cross-Regulation in Normal Intestine and Cancer. Front Endocrinol (Lausanne) (2021) 12:1–8. doi:10.3389/fendo.2021.725708

• Godart M, Frau C, Farhat D, Giolito MV, Jamard C, Le Nevé C, Freund JN, Penalva LO, Sirakov M, Plateroti M. The murine intestinal stem cells are highly sensitive to the modulation of the T3/TRα1-dependent pathway. DEVELOPMENT (2021) 148: doi:doi: 10.1242/dev.194357

• Sirakov M, Boussouar AA, Kress E, Frau C, Lone IN, Nadjar J, Angelov D, Plateroti M. The thyroid hormone nuclear receptor TRα1 controls the Notch signaling pathway and cell fate in murine intestine. Dev (2015) 142:2764–2774. doi:10.1242/dev.121962

• Sirakov M, Kress E, Nadjar J, Plateroti M. Thyroid hormones and their nuclear receptors: new players in intestinal epithelium stem cell biology? Cell Mol LIFE Sci (2014)

• Sirakov M*, Borra M, Cambuli FM, Plateroti M. Defining Suitable Reference Genes for RT-qPCR Analysis on Intestinal Epithelial Cells. Mol Biotechnol (2013) 54:930–938. doi:10.1007/s12033-012-9643-3

• Sirakov M, Plateroti M. The thyroid hormones and their nuclear receptors in the gut: From developmental biology to cancer. Biochim Biophys Acta - Mol Basis Dis (2011) 1812:938–946. doi:10.1016/j.bbadis.2010.12.020

• Sirakov M, Zarrella I, Borra M, Rizzo F, Biffali E, Arnone M.I., Fiorito G. Selection and validation of a set of reliable reference genes for quantitative RT-PCR studies in the brain of the Cephalopod Mollusc Octopus vulgaris. BMC Mol Biol (2009) 10: doi:10.1186/1471-2199-10-70

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