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Terzibasi TozziniResearcher
Biology and Evolution of Marine Organisms Department

Tel.: +39 081 5833322
e-mail: eva.terzibasi(at)szn.it
Contatto Skype: eva terzibasi tozzini
Google scholar: https://scholar.google.com/citations?user=cpkslV4AAAAJ&hl=en

Curriculum Vitae


Research Interests

I graduated in Marine Biology and specialized during my PhD and postdoc in the neurobiology of a short-lived aquatic vertebrate model, focusing my studies on aging, neurodegeneration, adult neurogenesis and circadian rhythms. The neural adaptation of marine vertebrates to different environments and environmental changes is a topic that has been poorly investigated until now. My research interest focuses on the study of the neurobiology of marine organisms in an evolutionary and eco-physiological perspective, and in particular on: 1. Comparative studies on the organization of the CNS in different species of basal marine vertebrates in the phylogenetic tree of chordates, with particular attention to neuroanatomy and distribution of neurogenic niches 2. Study of the evolution of neurotrophins: after a first whole genome duplication in cyclostomes, a second duplication event occurred in chondrichthyans during the evolution, suggesting the appearance of four different neurotrophins and related receptors in this aquatic basal group. The comparative analysis of neurotrophins expression in the lamprey (Petromizon marinus) and different species of chondrichthyans (in particular, Scyliorhinus canicula) will add new advances applicable to conventional and unconventional model systems, contributing significantly to the neurobiology of marine vertebrates - 3. Study of aging and age-related processes in cartilaginous fish: the shark of Greenland, Somniosus microcephalus, is the longest lived vertebrate, with a life expectancy of over 270 years, based on radiocarbon dating in the cornea. The idea is to carry out a comparative study between S. microcephalus and other sister species (such as the mediterranean ) to analyze the evolution of the variation of life history traits in vertebrates under genetic and neuro-anatomical aspect. Due to the important functional role of the nervous system in an organism's adaptive response to its specific environment, a deeper understanding of active neural processes, such as adult neurogenesis and neurodegeneration, could be a key factor in more effective health monitoring. organisms and the general equilibrium of the ecosystem itself.

Selected Publications

Di Cicco E, Tozzini ET, Rossi G, Cellerino A. (2011). The short-lived annual fish Nothobranchius furzeri shows a typical teleost aging process reinforced by high incidence of age-dependent neoplasias. Exp Gerontol. 46(4):249-56. doi: 10.1016/j.exger.2010.10.011. Citato da Cell Previews

Tozzini ET, Baumgart M, Battistoni G, Cellerino A. (2012). Adult neurogenesis in the short-lived teleost Nothobranchius furzeri: localization of neurogenic niches, molecular characterization and effects of aging. Aging Cell. 11(2):241-51. doi: 10.1111/j.1474-9726.2011.00781.x. Commentato da Faculty of 1000

D'Angelo L, de Girolamo P, Lucini C, Terzibasi ET, Baumgart M, Castaldo L, Cellerino A. (2013) Brain derived neurotrophic factor: mRNA expression and protein distribution in the brain of the teleost Nothobranchius furzeri. J Comp Neurol. doi: 10.1002/cne.23457.

Tozzini ET, Dorn A, Ng'oma E, Polačik M, Blažek R, Reichwald K, Petzold A, Watters B, Reichard M, Cellerino A. (2013). Parallel evolution of senescence in annual fishes in response to extrinsic mortality. BMC Evol Biol. 3;13:77. doi: 10.1186/1471-2148-13-77.

Terzibasi Tozzini E, Savino A, Ripa R, Battistoni G, Baumgart M, Cellerino A. (2014). Regulation of microRNA expression in the neuronal stem cell niches during aging of the short-lived annual fish Nothobranchius furzeri. Front Cell Neurosci. 21;8:51. doi: 10.3389/fncel.2014.00051.

Baumgart M, Groth M, Priebe S, Savino A, Testa G, Dix A, Ripa R, Spallotta F, Gaetano C, Ori M, Terzibasi Tozzini E, Guthke R, Platzer M, Cellerino A. (2014). RNA-seq of the aging brain in the short-lived fish N. furzeri - conserved pathways and novel genes associated with neurogenesis. Aging Cell. 13(6):965-74. doi: 10.1111/acel.12257.

Baumgart M, Di Cicco E, Rossi G, Cellerino A, Tozzini ET. (2015)Comparison of captive lifespan, age-associated liver neoplasias and age-dependent gene expression between two annual fish species: Nothobranchius furzeri and Nothobranchius korthause. Biogerontology. 16(1):63-9. doi: 10.1007/s10522-014-9535-y. Commentato da Faculty of 1000

Blažek R, Polačik M, Kačer P, Cellerino A, Řežucha R, Methling C, Tomášek O, Syslová K, Terzibasi Tozzini E, Albrecht T, Vrtílek M, Reichard M. (2016). Repeated intraspecific divergence in life span and aging of African annual fishes along an aridity gradient. Evolution 71 (2), 386-402. Doi: 10.1111/evo.13127

Ripa R, Dolfi L, Terrigno M, Pandolfini L, Savino A, Arcucci V, Groth M, Terzibasi Tozzini E, Baumgart M, Cellerino A. (2017 MicroRNA miR-29 controls a compensatory response to limit neuronal iron accumulation during adult life and aging. BMC Biol. 13;15(1):9. doi: 10.1186/s12915-017-0354-x. Citato da Nature News

Terzibasi-Tozzini E1, Martinez-Nicolas A, Lucas-Sánchez A. (2017). The clock is ticking. Ageing of the circadian system: from physiology to cell cycle. Semin Cell Dev Biol. pii: S1084-9521(16)30309-3. doi: 10.1016/j.semcdb.2017.06.011.

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