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Biology and Evolution of Marine Organisms Department

Stazione Zoologica Anton Dohrn
Villa Comunale
80121 Napoli - Italia

Tel.: +39 081 5833252
E-mail: lorena.buono(at)szn.it

Curriculum Vitae

Research Interests

The functional and morphological characteristics of the cell are governed by complex interplays between the genome and the molecular regulators orchestrating the expression levels of RNAs and proteins. These intricate webs of interactions among diverse cellular components are called gene regulatory networks (GRNs), which are essential for the regulation of cellular processes, tissue development, growth and differentiation. Since changes in these networks can result in significant shifts in the phenotype of an organism, affecting its morphology and
functional development, they also play a key role in steering evolutionary trajectories. The primary focus of our group is the computational modeling of GRNs through the integration of a diverse set of high-throughput sequencing data, aiming at a deeper and nuanced understanding of genetic programs and evolutionary patterns underlying developmental processes.

Selected Publications

1. Letelier J#, Buono L#, Almuedo-Castillo M, Zang J, Mounieres C, González-Díaz S, Polvillo R, Sanabria-Reinoso E, Corbacho J, Sousa-Ortega A, Diez Del Corral R, Neuhauss SCF, Martínez-Morales JR. Mutation of vsx genes in zebrafish highlights the robustness of the retinal specification network. Elife. 2023 May 25;12:e85594. #Authors equally contributed

2. Sousa-Ortega A, Vázquez-Marín J, Sanabria-Reinoso E, Corbacho J, Polvillo R, Campoy-López A, Buono L, Loosli F, Almuedo-Castillo M, Martínez-Morales JR. A Yap-dependent mechanoregulatory program sustains cell migration for embryo axis assembly. Nat Commun. 2023 May 16;14(1):2804.

3. Corbacho J, Sanabria-Reinoso E, Buono L, Fernández-Miñan A, Martínez-Morales JR. Trap-TRAP, a Versatile Tool for Tissue-Specific Translatomics in Zebrafish. Front Cell Dev Biol. 2022 Jan 31;9:817191.

4. Buono L, Iside C, De Matteo A, Stellato P, Beneduce G, de Vera d'Aragona RP, Parasole R, Salvatore M, Smaldone G, Mirabelli P. Specific lncRNA signatures discriminate childhood acute leukaemias: a pilot study. Cancer Cell Int. 2022 Nov 30;22(1):373.

5. Buono L, Corbacho J, Naranjo S, Almuedo-Castillo M, Moreno-Marmol T, de la Cerda B, Sanabria-Reinoso E, Polvillo R, Díaz-Corrales FJ, Bogdanovic O, Bovolenta P, Martínez-Morales JR. Analysis of gene network bifurcation during optic cup morphogenesis in zebrafish. Nat Commun. 2021 Jun 23;12(1):3866.

6. Fuhrmann JF, Buono L, Adelmann L, Martinez-Morales JR, Centanin L. Genetic developmental timing revealed by inter-species transplantations in fish. Development. 2020 Nov 23;147(22):dev192500.

7. Buono L, Martinez-Morales JR. Retina Development in Vertebrates: Systems Biology Approaches to Understanding Genetic Programs: On the Contribution of Next-Generation Sequencing Methods to the Characterization of the Regulatory Networks Controlling Vertebrate Eye Development. Bioessays. 2020 Apr;42(4):e1900187.

8. Vázquez-Marín J, Gutiérrez-Triana JA, Almuedo-Castillo M, Buono L, Gómez-Skarmeta JL, Mateo JL, Wittbrodt J, Martínez-Morales JR. yap1b, a divergent Yap/Taz family member, cooperates with yap1 in survival and morphogenesis via common transcriptional targets. Development. 2019 Jun 21;146(13):dev173286.

9. Stolper J, Ambrosio EM, Danciu DP, Buono L, Elliott DA, Naruse K, Martínez-Morales JR, Marciniak-Czochra A, Centanin L. Stem cell topography splits growth and homeostatic functions in the fish gill. Elife. 2019 May 16;8:e43747.

10. Marlétaz F, Firbas PN, Maeso I, Tena JJ, Bogdanovic O, Perry M, Wyatt CDR, de la Calle-Mustienes E, Bertrand S, Burguera D, Acemel RD, van Heeringen SJ, Naranjo S, Herrera-Ubeda C, Skvortsova K, Jimenez-Gancedo S, Aldea D, Marquez Y, Buono L, Kozmikova I, Permanyer J, Louis A, Albuixech-Crespo B, Le Petillon Y, Leon A, Subirana L, Balwierz PJ, Duckett PE, Farahani E, Aury JM, Mangenot S, Wincker P, Albalat R, Benito-Gutiérrez È, Cañestro C, Castro F, D'Aniello S, Ferrier DEK, Huang S, Laudet V, Marais GAB, Pontarotti P, Schubert M, Seitz H, Somorjai I, Takahashi T, Mirabeau O, Xu A, Yu JK, Carninci P, Martinez-Morales JR, Crollius HR, Kozmik Z, Weirauch MT, Garcia-Fernàndez J, Lister R, Lenhard B, Holland PWH, Escriva H, Gómez-Skarmeta JL, Irimia M. Amphioxus functional genomics and the origins of vertebrate gene regulation. Nature. 2018 Dec;564(7734):64-70.

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