Post Doc
Biology and Evolution of Marine Organisms Department
Stazione Zoologica Anton Dohrn
Villa Comunale
80121 Napoli - Italia
Tel: +39 081 5833211
e-mail: ennio.silvestri(at)szn.it
ORCID: 0000-0003-3559-100X
ERC sectors - Cellular, developmental and regenerative biology (LS3), Integrative biology: from genes and genomes to systems (LS2)
Settori scientifico-disciplinari - Anatomia comparata e citologia (BIO/06), Biologia molecolare (BIO/11)
Research Interests
I earned my MSc in Molecular and Cell Biology in 2018 from the University of Siena, completing my degree under the supervision of Prof. Federico Galvagni focusing on neovascular Age-related macular degeneration. That same year, I gained my first international research experience at UCL London, in the lab of Prof. Stephen Moss. I bred mice, learned how to handle animal biopsies, and established ex-vivo choroidal assays.
Later, in Geneva, Switzerland, under the mentorship of Prof. Patrick Meraldi, I pursued a Ph.D. in biomedical studies. I studied the role of the mitotic kinase Aurora-A in chromosomal instability, Aurora-A is one of the most infamous kinases in oncological research. During my PhD studies, I developed broad expertise in cell biology and optical microscopy. I developed an innovative optogenetic technique that uses light pulses to manipulate the mitotic division of transformed human cell lines.
In 2024, I began my first postdoc at SZN Anton Dohrn in Naples, in Dr. Ina Arnone's lab. I was captivated by the beauty of marine cellular and developmental biology. Here, I used my microscopy skills to observe changes in the formation of the Golgi ribbon during sea urchin embryo early stages of development.
Currently, in collaboration with Dr. Mariella Ferrante, I am interested in the ultrastructure of diatoms during their life cycle. I am integrating common immunohistochemistry and expansion microscopy to study these cells living in a glass house.
Selected Publications
- SILVESTRI, Ennio. Overactive Aurora-A At Spindle Poles In Prometaphase Disrupts Mitotic Progression. Doctoral Thesis, 2023. https://doi.org/10.13097/archive-ouverte/unige:174510
-Mundo, L.; Tosi, G.M.; Lazzi, S.; Pertile, G.; Parolini, B.; Neri, G.; Posarelli, M.; De Benedetto, E.; Bacci, T.; SILVESTRI, E.; et al. LRG1 Expression Is Elevated in the Eyes of Patients with Neovascular Age-Related Macular Degeneration. Int. J. Mol. Sci. 2021, 22, 8879. https://doi.org/10.3390/ijms22168879
